• Armor sets come in two pieces, body and head
  
• Inventory limit is based on weight
  
• Children and essential NPC's are unkillable
  
• Good/Evil karma system relating to in-game choices
  
• Crimes committed against specific groups are known to all in the group throughout the game world
  
• NPC's navigate via a mesh instead of via a point to point system like in Oblivion and Morrowind
  
• Like Oblivion the game uses a skill list and those skills determine maximum possible effectiveness in battle
  
• Faces are customizable, but not bodies
  
• The player can crouch and sneak around
  
• Many of the old Fallout traits return, only now as skill perks
  
• Fast travel is only available to places you've been before
  
• Not all non-humans are hostile: "some can be reasoned with and even hired."
  
• Player "perception" functions like the Oblivion compass
  

• Rumor: Fallout 3 denied classification in Australia
• Bethesda, Amazon introduce Fallout 3 Survival Edition
  

Via Bethesda